Frequently Asked Questions

Nixulin™ was born from a growing need to address the root cause of insulin resistance—the metabolic dysfunction underlying type 2 diabetes and prediabetes. While many existing treatments focus on blood sugar control through medication or hormone signaling, Nixulin™ emerged from a radically different perspective: restoring cellular signaling balance through natural means.

At the heart of this innovation is Diethyl Azelate (DEA), a naturally occurring ester of azelaic acid found in plants, fermented foods, and produced by the human body itself. DEA’s therapeutic potential had been largely overlooked until researchers discovered its ability to modulate cell membrane fluidity, a mechanism now known to play a vital role in insulin sensitivity, fat metabolism, leptin signaling, and glucose uptake.

Nixulin™ offers an oral, non-pharmaceutical option with no known side effects, making it ideal for long-term use. It works by enhancing impaired insulin sensitivity, modulating SGLT-1 activity, and restoring proper leptin and metabolic signaling—without compromising the body’s natural glucose balance.

Today, Nixulin™ stands as the first and only supplement harnessing the power of DEA, backed by U.S. patents, clinical data, and a commitment to science-driven wellness. It’s not just another blood sugar supplement—it’s a new standard in natural metabolic support.

Nixulin™ is intended for adults seeking a natural, non-pharmaceutical way to support healthy blood sugar levels—particularly those with prediabetes, type 2 diabetes, or metabolic syndrome. Individuals with A1C levels of 5.5% or above often benefit the most, as Nixulin™ is designed to improve impaired insulin sensitivity, a key underlying issue in early-stage metabolic dysfunction.

Nixulin™ is safe for long-term daily use and has no known side effects, making it a reliable option for ongoing metabolic support. However, it is not recommended for children under 18, or for individuals who are pregnant or nursing. As with any supplement, please consult your healthcare provider before use, especially if you have a medical condition or take prescription medications.

For more details, check out How Nixulin™ Influences Impaired Insulin Sensitivity

Yes. Nixulin™ is particularly promising for individuals with prediabetes because it helps address impaired insulin sensitivity, a key underlying driver of elevated blood sugar. Its patented Insulin Sensitivity Technology™ is clinically shown to improve the body’s response to insulin, support glucose metabolism, and reduce post-meal sugar spikes.

Many users appreciate that Nixulin™ is a natural, non-pharmaceutical option with no reported side effects—a major advantage for those seeking safe, long-term daily support. If you’re managing prediabetes, Nixulin™ will serve you as a helpful complement to your lifestyle adjustments and wellness routine in preventing progression to type 2 diabetes.

For more details, check out How Nixulin™ Influences Impaired Insulin Sensitivity

As a dietary supplement, adults take one capsule or one 1 mL per day, or as recommended by a healthcare professional. Nixulin™ should be taken every day in the morning before meals.

According to multiple studies, lowering blood sugar levels or supporting weight loss requires consistent pharmacological or nutraceutical concentrations over 24 hours, regardless of dosing intervals. A once-daily dose of Nixulin™ ensures consistent concentrations throughout the day, with its effects tapering off slowly during the first 24 hours and more rapidly after. It typically takes about five days to reach a steady state of response. That is why strictly adhering to a daily dose of Nixulin™ is essential for achieving the desired results.

Nixulin™ has no known side effects, so it can be a part of your daily routine, supporting healthy blood sugar levels and glucose metabolism for as long as you and your healthcare professional deem necessary.

Results will depend on your age, gender, weight, height, physical characteristics, diet, and exercise. However, even with non-compliant users, decreases in fasting plasma glucose levels can be seen within the first 7 to 10 days, and noticeable changes in other markers by the end of the first 30 days.

Yes, it will indeed. Powered by patented Insulin Sensitivity Technology, Nixulin™ targets the root cause of sugar spikes—impaired insulin sensitivity—with just one daily dose. In clinical studies, the average postprandial glucose decrease was 13.5%, and for those with high A1C levels, the reduction was even more significant, averaging 21.7%.

To keep your sugar spikes under control, take your Nixulin™ once daily 15 minutes before your breakfast meal. Have a festive dinner planned and worried about your blood sugar levels? Then take your Nixulin™ that day 15 minutes before your holiday or birthday meal to help keep your blood sugar in check.

If your A1C levels are 5.5% or higher, you may wish to consider a blood sugar support product such as Nixulin™ to help maintain healthy blood sugar levels. Consult your healthcare professional if you are concerned about your risk of high A1C levels.

For more details, check out What Are A1C Levels And What Do They Mean?

The latest independent 3-month clinical study of Nixulin™ as an adjuvant treatment for uncontrolled type 2 diabetes supported the benefits of using Nixulin™ alongside regular medications to manage uncontrolled type 2 diabetes.

Thus, after one month of using Nixulin™ as an adjuvant treatment:
    1. 34% reduction in fasting insulin levels
    2. 8.1% reduction in total cholesterol levels

After three months of using Nixulin™ as an adjuvant treatment:
    3. 36.9% reduction in fasting glucose levels
    4. 38.7% reduction in 2-hour postprandial glucose levels
    5. 12% reduction in HbA1c levels

Please talk with your healthcare professionals before using Nixulin™ as an adjuvant treatment for uncontrolled type 2 diabetes.  Additionally, monitor your blood sugar levels closely while taking Nixulin™ to avoid hypoglycemia (low blood sugar).

The latest independent 3-month clinical study of Nixulin™ as an adjuvant treatment for uncontrolled type 2 diabetes supported the benefits of using Nixulin™ alongside Metformin and Glimepiride at maximum dosage to help lower sugar levels without increasing the medication dosage.

Thus, after one month of using Nixulin™ as an adjuvant treatment:
    1. 34% reduction in fasting insulin levels
    2. 8.1% reduction in total cholesterol levels

After three months of using Nixulin™ as an adjuvant treatment:
    3. 36.9% reduction in fasting glucose levels
    4. 38.7% reduction in 2-hour postprandial glucose levels
    5. 12% reduction in HbA1c levels

Please talk with your healthcare professionals before using Nixulin™ as an adjuvant treatment to prescribed diabetic medication. Additionally, monitor your blood sugar levels closely while taking Nixulin™ to avoid hypoglycemia (low blood sugar).

For long-term management, it's best to take Nixulin™ at a consistent time each day. The timing depends on your personal diet. If you have a heavy breakfast, take Nixulin™ before breakfast. However, if you have a heavier dinner, take Nixulin™ before dinner. If your meals vary in size, take Nixulin™ before your biggest meal of the day. In other words, always take Nixulin™ before the meal that tends to have the most sugar or carbohydrates. The key is consistency and taking Nixulin™ before the meal that will most impact your blood sugar.

Nixulin™ contains just three carefully selected all-natural ingredients: Diethyl Azelate (DEA) and the combination of Biotin and Chromium Picolinate.

• DEA – a patented ester naturally found in plants and fermented foods

• Biotin – a B-vitamin found in plants, dairy products, meat, and eggs

• Chromium Picolinate – an essential mineral commonly found in lean meats and plant-based foods

These ingredients work together to support healthy insulin sensitivity, blood sugar levels, cardiovascular health, and weight management.

Diethyl Azelate (DEA) is a key active ingredient in Nixulin™. DEA is an ester of azelaic acid — a naturally occurring compound found in plants, animals, and humans. DEA is naturally produced by the human body, supporting healthy immune responses. More specifically, DEA modulates the transfer of cellular signals responsible for critical processes, including blood sugar balance and insulin responses.

For more details, check out Nixulin™ and Its Primary Lead Compound—Diethyl Azelate

Yes, the active ingredients in Nixulin™ are all-natural. They are carefully selected to support healthy insulin sensitivity, blood sugar levels, cardiovascular health, and glucose metabolism.

Yes, Nixulin™ is free of dairy, egg, starch, yeast, barley, rye, wheat, and other gluten-containing ingredients.

No, Nixulin™ does not contain any stimulants. It is formulated to support healthy blood sugar levels without the use of stimulant ingredients.

We don't use magnesium stearate, whether from animal or vegetable sources, in our products because research indicates it may convert into formaldehyde, which can cause metabolic stress. Formaldehyde is also recognized as a carcinogen by the U.S. Department of Health and Human Services

There are none of the known side effects. Nixulin™ is formulated with natural, safe ingredients, and for most people, it is generally well-tolerated without any side effects. However, as with any supplement, individual reactions can vary. 

Yes, Nixulin™ is considered safe for use by adults looking to support blood sugar balance, insulin sensitivity, and metabolic health. It is designed for once-daily use and is suitable for long-term supplementation. Nixulin™ has demonstrated a favorable safety profile in clinical and lab studies, is built from ingredients widely recognized as safe, and is manufactured in FDA-registered, GMP-certified U.S. facilities.

Nixulin™ does not contain any compounds that are known to be addictive or habit-forming.

We recommend that you consult with a healthcare professional, who is familiar with your medications and medical history.

Nixulin™ is not recommended for anyone under 18, pregnant, or nursing. Also, Nixulin™ is not recommended for people with A1C less than 5.5. Please talk with your healthcare professional before using Nixulin™.

No, Nixulin™ is not FDA-approved. Dietary supplements, like Nixulin™, are not subject to FDA approval in the same way prescription drugs are. However, Nixulin™ and its claims are properly registered with the FDA, and all Nixulin™ ingredients comply with the latest FDA regulations.

Nixulin™ is wholly manufactured and packaged in the USA in an FDA-registered, GMP-certified facility, and third-party lab tested to ensure its potency, quality, and safety.

Nixulin™ should be stored in a cool, dark, and dry place.

Yes, qualified customers can pay for Nixulin™ with their HSA or FSA funds. Paying with HSA/FSA results in an average of 30% extra savings.

For more details, check out From Saving to Thriving: How HSA/FSA Shopping Can Enhance Your Health Journey

Yes! We offer an exclusive discount for:
- Current and former U.S. military
- Military spouses and dependents
- First responders, including law enforcement, fire, and EMS
- Federal, state, and local government employees
- Teachers (K-12 and University teachers/staff)

For more details, check out Savings For Those Who Serve

Yes—we understand how important access to blood sugar support is. That’s why we offer the Nixulin™ Financial Assistance Program to help individuals on a fixed income or facing financial hardship.

To apply:
• Email a short note to support@nixulin.com explaining your situation
• Or fill out the request form on our website

No documentation is required unless specifically requested, and all requests are handled confidentially. Most applicants receive a response within a few business days. There’s no obligation to apply—this program is here to help make Nixulin™ more accessible for those who need it.

We create our special subscription prices to ease the financial burden on those who have to take our Nixulin™ on a permanent basis.

Subscribe & Save up to 41.7%

Oral Glucose Tolerance Tests (OGTT) measure how well the body can process more significant amounts of sugar. If the blood sugar reading is above a certain level, this could be a sign that sugar is not being absorbed fast enough by the body’s organs, and then diabetes might be at the root of this problem.

To test your post-meal (postprandial) blood sugar level, the recommended timing is 1.5 to 2 hours after the start of a meal. This window captures the typical peak in blood glucose levels and gives the most relevant insight into how your body is processing the meal.